Novel 10-bp deletion in the translational attenuator of a constitutively expressed erm(A) gene from Staphylococcus epidermidis.
نویسندگان
چکیده
Alterations in the erm(A) regulatory region of six clinical isolates of Staphylococcus epidermidis and one of Staphylococcus haemolyticus displaying a constitutive resistance phenotype were investigated. Anovel deletion of 10 bp with respect to the corresponding sequence of Tn554 was identified in the attenuator of a constitutively expressed erm(A) gene of one of the S. epidermidis isolates. Thus far, this is the smallest deletion conferring constitutive resistance in the translational attenuator of erm(A) in a naturally occurring S. epidermidis strain of human origin.
منابع مشابه
Characterization of the translational attenuator of 20 methicillin-resistant, quinupristin/dalfopristin-resistant Staphylococcus aureus isolates with reduced susceptibility to glycopeptides.
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متن کاملکاربری پروتیین‌های جدید در ساخت واکسن استافیلوکوکوس اورئوس
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OBJECTIVES To study the regulatory region of a constitutively expressed erm(A) gene in Streptococcus agalactiae clinical isolates. METHODS Thirty clinical isolates of S. agalactiae which were cross-resistant to erythromycin and clindamycin and with a clindamycin MIC higher than that of erythromycin were studied by PCR, sequencing and molecular typing. RESULTS PCR analysis revealed that all ...
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ورودعنوان ژورنال:
- International microbiology : the official journal of the Spanish Society for Microbiology
دوره 10 2 شماره
صفحات -
تاریخ انتشار 2007